DeCS Server - List Exact Term

Search on:	ATP-BINDING CASSETTE, SUB-FAMILY B PROTEINS
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DeCS

Descriptor English:

P-Glycoproteins

Descriptor Spanish:

Glicoproteínas P

Descriptor Portuguese:

Glicoproteínas P

Synonyms English:

ATP-Binding Cassette, Sub-Family B Proteins
ATP Binding Cassette, Sub Family B Proteins
P Glycoproteins
Multidrug Resistance Proteins

Tree Number:

Definition English:

A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P-GLYCOPROTEIN. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.

Indexing Annotation English:

P-GLYCOPROTEIN is also available; P stands for "permeability"

See Related English:

History Note English:

99; use P-GLYCOPROTEIN 1995-98

Allowable Qualifiers English:

Record Number:

33637

Unique Identifier:

D018435

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